Genetic control of invasive fish species
This project focuses on a novel method of biocontrol for common carp which will complement existing technologies by introducing a synthetic species-like barrier to reproduction. Researchers will use programmable transcription activators to drive lethal embryonic overexpression of endogenous genes in hybrid embryos. Applications for this synthetic incompatibility could include population control of pest or invasive species or be utilized to prevent the spread of transgenes from genetically modified aquatic organisms to sexually reproducing wild populations.
The method involves altering the genetics of males in the invasive species before releasing them among the population, leading to sterile offspring and the eventual control of the species overall. In order to make this method usable, this study aims to develop this technology further in zebrafish, from which the system can be applied to other invasive fish species and eventually other vertebrate pests.
This control method has promise to be very species-specific, broadly applicable, and cost-effective.
The overall goal of this project is to demonstrate a novel genetic approach for controlling aquatic invasive species using invasive common carp as proof-of-concept. This project will:
- Develop state-of-the-art carp transgenesis capabilities in the laboratory so researchers have year-round access to young carp embryos
- Begin transitioning the genetic biocontrol strategy – a species-like barrier to reproduction which has already been tested in simple laboratory organisms – into carp
- Use computer modeling to predict the efficacy of the approach
- Engage the public to better understand the attitudes and opinions regarding the use of genetically engineered organisms as part of an integrated pest management plan
If this project is successful, it could lead to implementation of this technology in other aquatic invasive species, including Asian carp and zebra mussels.